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UniProt is the world's leading high-quality, comprehensive, and freely accessible resource for protein sequence and functional annotation data. Maintained by the UniProt Consortium (EMBL-EBI, SIB, and PIR), it integrates information from experimental literature and computational analysis to provide a single authoritative source on protein function, taxonomy, sequences, cross-references, and disease associations. UniProt exposes a REST API at rest.uniprot.org for searching and retrieving entries from UniProtKB, UniRef, UniParc, Proteomes, and supporting services such as ID mapping. All data is freely available under Creative Commons Attribution 4.0.

7 APIs 0 Features
ProteinsBioinformaticsGenomicsLife SciencesOpen Data

APIs

UniProtKB REST API

Search and retrieve protein entries from UniProtKB, which integrates Swiss-Prot (manually reviewed) and TrEMBL (computationally annotated) databases. Supports full-text and fiel...

UniRef REST API

UniRef (UniProt Reference Clusters) groups similar sequences to reduce redundancy. UniRef100 combines identical sequences; UniRef90 clusters sequences sharing 90% identity; UniR...

UniParc REST API

UniParc (UniProt Archive) is a comprehensive non-redundant database of publicly available protein sequences. Each unique sequence appears once with a stable UniParc identifier a...

Proteomes REST API

Provides access to UniProt proteomes — the complete or near-complete sets of proteins from fully sequenced organisms. Supports retrieval of reference proteomes and gene-centric ...

ID Mapping REST API

Maps identifiers between UniProt accessions and over 150 external database identifiers (e.g., RefSeq, Ensembl, PDB, ChEMBL, KEGG, OMIM). Asynchronous job-based service: submit a...

UniProt SPARQL Endpoint

A standards-compliant SPARQL 1.1 endpoint exposing the full UniProt knowledge graph as RDF. The current release contains approximately 232 billion triples across 21 named graphs...

EBI Proteins REST API

The EMBL-EBI Proteins API provides integrated access to UniProt protein annotations alongside large-scale study data including variation data from 1000 Genomes, ClinVar, ExAC, C...

Semantic Vocabularies

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Raw ↑ 
name: UniProt
description: >
  UniProt is the world's leading high-quality, comprehensive, and freely
  accessible resource for protein sequence and functional annotation data.
  Maintained by the UniProt Consortium (EMBL-EBI, SIB, and PIR), it integrates
  information from experimental literature and computational analysis to provide
  a single authoritative source on protein function, taxonomy, sequences,
  cross-references, and disease associations. UniProt exposes a REST API at
  rest.uniprot.org for searching and retrieving entries from UniProtKB,
  UniRef, UniParc, Proteomes, and supporting services such as ID mapping.
  All data is freely available under Creative Commons Attribution 4.0.
image: https://www.uniprot.org/images/logos/uniprot.svg
url: https://www.uniprot.org/
tags:
  - Proteins
  - Bioinformatics
  - Genomics
  - Life Sciences
  - Open Data
created: "2002-01-01"
modified: "2026-06-13"
specificationVersion: "0.19"
apis:

  - name: UniProtKB REST API
    description: >
      Search and retrieve protein entries from UniProtKB, which integrates
      Swiss-Prot (manually reviewed) and TrEMBL (computationally annotated)
      databases. Supports full-text and field-specific queries, retrieval by
      accession, and streaming of large result sets. Returns rich protein
      records including sequences, functional annotations, cross-references,
      taxonomic lineage, subcellular location, disease associations, and
      literature citations.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://www.uniprot.org/help/api
    baseURL: https://rest.uniprot.org/uniprotkb
    version: "2026_01"
    tags:
      - Proteins
      - Sequences
      - Annotations
      - Swiss-Prot
      - TrEMBL
    properties:
      - type: Documentation
        url: https://www.uniprot.org/help/api
      - type: OpenAPI
        url: https://www.uniprot.org/help/api
      - type: TermsOfService
        url: https://www.uniprot.org/help/license
    contact:
      - FN: UniProt Consortium
        email: [email protected]
        url: https://www.uniprot.org/contact

  - name: UniRef REST API
    description: >
      UniRef (UniProt Reference Clusters) groups similar sequences to reduce
      redundancy. UniRef100 combines identical sequences; UniRef90 clusters
      sequences sharing 90% identity; UniRef50 clusters at 50%. The REST API
      allows searching and retrieving clusters with associated member lists.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://www.uniprot.org/help/uniref
    baseURL: https://rest.uniprot.org/uniref
    version: "2026_01"
    tags:
      - Proteins
      - Sequence Clusters
      - Redundancy Reduction
    properties:
      - type: Documentation
        url: https://www.uniprot.org/help/uniref
      - type: TermsOfService
        url: https://www.uniprot.org/help/license
    contact:
      - FN: UniProt Consortium
        email: [email protected]
        url: https://www.uniprot.org/contact

  - name: UniParc REST API
    description: >
      UniParc (UniProt Archive) is a comprehensive non-redundant database of
      publicly available protein sequences. Each unique sequence appears once
      with a stable UniParc identifier and cross-references to source databases.
      The REST API enables retrieval of sequence entries by accession or
      database cross-reference.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://www.uniprot.org/help/uniparc
    baseURL: https://rest.uniprot.org/uniparc
    version: "2026_01"
    tags:
      - Proteins
      - Sequences
      - Archive
    properties:
      - type: Documentation
        url: https://www.uniprot.org/help/uniparc
      - type: TermsOfService
        url: https://www.uniprot.org/help/license
    contact:
      - FN: UniProt Consortium
        email: [email protected]
        url: https://www.uniprot.org/contact

  - name: Proteomes REST API
    description: >
      Provides access to UniProt proteomes — the complete or near-complete sets
      of proteins from fully sequenced organisms. Supports retrieval of
      reference proteomes and gene-centric proteome data. Useful for whole-
      organism proteomics and comparative genomics workflows.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://www.uniprot.org/help/proteomes
    baseURL: https://rest.uniprot.org/proteomes
    version: "2026_01"
    tags:
      - Proteomes
      - Genomics
      - Comparative Biology
    properties:
      - type: Documentation
        url: https://www.uniprot.org/help/proteomes
      - type: TermsOfService
        url: https://www.uniprot.org/help/license
    contact:
      - FN: UniProt Consortium
        email: [email protected]
        url: https://www.uniprot.org/contact

  - name: ID Mapping REST API
    description: >
      Maps identifiers between UniProt accessions and over 150 external
      database identifiers (e.g., RefSeq, Ensembl, PDB, ChEMBL, KEGG, OMIM).
      Asynchronous job-based service: submit a mapping job, poll for completion,
      then fetch paginated results. Supports bulk conversion of thousands of
      identifiers in a single request.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://www.uniprot.org/help/id_mapping
    baseURL: https://rest.uniprot.org/idmapping
    version: "2026_01"
    tags:
      - ID Mapping
      - Cross-references
      - Identifiers
    properties:
      - type: Documentation
        url: https://www.uniprot.org/help/id_mapping
      - type: TermsOfService
        url: https://www.uniprot.org/help/license
    contact:
      - FN: UniProt Consortium
        email: [email protected]
        url: https://www.uniprot.org/contact

  - name: UniProt SPARQL Endpoint
    description: >
      A standards-compliant SPARQL 1.1 endpoint exposing the full UniProt
      knowledge graph as RDF. The current release contains approximately 232
      billion triples across 21 named graphs. Supports complex biological
      queries joining protein sequences, annotations, taxonomy, pathways, and
      cross-references. Powered by QLever. Query timeout is 45 minutes.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://sparql.uniprot.org/
    baseURL: https://sparql.uniprot.org/sparql
    version: "2026_01"
    tags:
      - SPARQL
      - RDF
      - Semantic Web
      - Knowledge Graph
    properties:
      - type: Documentation
        url: https://sparql.uniprot.org/
      - type: TermsOfService
        url: https://www.uniprot.org/help/license
    contact:
      - FN: UniProt Consortium
        email: [email protected]
        url: https://www.uniprot.org/contact

  - name: EBI Proteins REST API
    description: >
      The EMBL-EBI Proteins API provides integrated access to UniProt protein
      annotations alongside large-scale study data including variation data from
      1000 Genomes, ClinVar, ExAC, COSMIC, gnomAD, and TCGA; proteomics
      evidence from PeptideAtlas and MaxQB; antigen and epitope annotations;
      and coordinate mappings. Rate-limited to 200 requests per second per user.
    image: https://www.uniprot.org/images/logos/uniprot.svg
    humanURL: https://www.ebi.ac.uk/proteins/api/doc/
    baseURL: https://www.ebi.ac.uk/proteins/api
    version: "1"
    tags:
      - Proteins
      - Variation
      - Proteomics
      - Bioinformatics
    properties:
      - type: Documentation
        url: https://www.ebi.ac.uk/proteins/api/doc/
      - type: TermsOfService
        url: https://www.ebi.ac.uk/about/terms-of-use
    contact:
      - FN: EMBL-EBI Support
        url: https://www.ebi.ac.uk/about/contact

maintainers:
  - FN: UniProt Consortium
    email: [email protected]
    url: https://www.uniprot.org/contact