Cradle

aid: cradle-bio
name: Cradle
description: >-
  Cradle is a Dutch–Swiss biotechnology software company founded in 2021
  with headquarters in Amsterdam and an office in Zurich, building an
  AI-powered protein engineering platform for industrial biotech and
  biopharma R&D teams. The platform combines proprietary generative AI
  models — trained on billions of natural protein sequences and on data
  produced in Cradle's own Amsterdam wet lab — with a web application and
  REST API/Python SDK so that scientists can design, simulate, and
  co-optimize amino-acid sequence variants across multiple measurable
  properties such as activity, binding affinity, stability, expression,
  and developability. Core platform capabilities include AI candidate
  generation, multi-property co-optimization, virtual plate design,
  experimental data management with full versioning and audit trails,
  task orchestration (analyze data, diversify, engineer, select, search,
  train) across modalities including antibodies/mAbs, enzymes, vaccines,
  therapeutic peptides, and food ingredients, plus a Custom Predictors
  framework letting customers plug in their own ML models. Cradle is sold
  as enterprise SaaS to R&D organizations — disclosed customers and
  partners include Johnson & Johnson Janssen, Bayer, Novozymes/Novonesis,
  and Twist Bioscience, with the platform serving six of the top 25
  global pharma companies and over 50 active R&D programs. The company
  has raised approximately $115M to date across a seed round (Index
  Ventures, 2022), a $24M Series A (Index Ventures, 2023), and a $73M
  Series B (IVP, 2024). Co-founders are Stef van Grieken (CEO), Jelle
  Prins, Elise de Reus, Eli Bixby, and Harmen van Rossum.
type: Index
position: Provider
access: 3rd-Party
image: https://kinlane-productions.s3.amazonaws.com/apis-json/apis-json-logo.jpg
tags:
  - Protein Engineering
  - Generative Biology
  - Generative AI
  - Foundation Models
  - Machine Learning
  - Biotechnology
  - Biopharma
  - Drug Discovery
  - Antibody Discovery
  - Enzyme Engineering
  - Vaccines
  - Therapeutic Peptides
  - Industrial Biotech
  - Synthetic Biology
  - Computational Biology
  - Wet Lab
  - Life Sciences
  - Custom Predictors
url: https://raw.githubusercontent.com/api-evangelist/cradle-bio/refs/heads/main/apis.yml
created: '2026-05-25'
modified: '2026-05-25'
specificationVersion: '0.20'
apis:
  - aid: cradle-bio:cradle-platform-api
    name: Cradle Platform API
    tags:
      - Protein Engineering
      - Workspaces
      - Projects
      - Rounds
      - Data Management
      - Tables
      - Data Loads
      - Artifacts
      - Tasks
      - Audit Logs
      - Custom Predictors
    humanURL: https://docs.cradle.bio/api/
    baseURL: https://app.cradle.bio/v2
    properties:
      - type: Documentation
        url: https://docs.cradle.bio/api/
      - type: GettingStarted
        url: https://docs.cradle.bio/docs/getting-started/overview/
      - type: SDK
        url: https://docs.cradle.bio/sdk/cradle/sdk/
      - type: PythonSDKPackage
        url: https://pypi.org/project/cradle-sdk/
      - type: CustomPredictorTemplate
        url: https://github.com/cradlebio/custom-predictor-template
      - type: SignIn
        url: https://app.cradle.bio
    description: >-
      The Cradle Platform API is an enterprise REST API for programmatic
      access to Cradle's AI-driven protein engineering platform. It is
      organized under per-workspace v2 endpoints and exposes resource
      groups for Workspaces, Projects, Rounds, Data Management, Tables,
      Data Loads (file upload/download with finalize, undo, and redo),
      Artifacts, Tasks, Audit Logs, and Custom Predictors. Task creation
      endpoints (analyze-data/v2, diversify/v2, engineer/v2, select/v2,
      search/v2, train/v2) drive Cradle's core generative protein
      workflows — sequence diversification, multi-property
      co-optimization, candidate selection, similarity search, and
      model fine-tuning — and return artifacts that can be inspected,
      pulled into custom pipelines, or chained into downstream lab
      automation. The API is paired with an official Python SDK
      (`cradle-sdk` on PyPI) and a Custom Predictor framework that lets
      customers register internally developed models against the same
      orchestration surface used by the Cradle web application. Access
      is enterprise-gated (no public self-serve tier); authentication
      and SSO are handled at the workspace level with SOC 2 controls,
      and the spec is rendered as ReDoc-based reference rather than
      published as a downloadable OpenAPI file.
common:
  - type: Website
    url: https://www.cradle.bio
  - type: Platform
    url: https://www.cradle.bio/platform
  - type: Application
    url: https://app.cradle.bio
  - type: Documentation
    url: https://docs.cradle.bio
  - type: APIReference
    url: https://docs.cradle.bio/api/
  - type: SDK
    url: https://docs.cradle.bio/sdk/cradle/sdk/
  - type: Blog
    url: https://www.cradle.bio/blog
  - type: Careers
    url: https://www.cradle.bio/careers
  - type: Security
    url: https://www.cradle.bio/security
  - type: PyPIPackage
    url: https://pypi.org/project/cradle-sdk/
  - type: GitHubOrganization
    url: https://github.com/cradlebio
  - type: BoltzModel
    url: https://github.com/cradlebio/boltz
  - type: CustomPredictorTemplate
    url: https://github.com/cradlebio/custom-predictor-template
  - type: Bioutils
    url: https://github.com/cradlebio/bioutils
  - type: LinkedIn
    url: https://www.linkedin.com/company/cradlebio
  - type: Twitter
    url: https://twitter.com/cradlebio
  - type: GoogleCloudCaseStudy
    url: https://cloud.google.com/customers/cradlebio
  - type: BayerPartnership
    url: https://www.bayer.com/en/us/news-stories/ai-enabled-antibody-discovery-and-optimization
  - type: Wikipedia
    url: https://en.wikipedia.org/wiki/Cradle_(company)
maintainers:
  - FN: Kin Lane
    email: [email protected]